San Francisco 49ers star wide receiver Deebo Samuel is on the trade block, and there should be no shortage of interest in the 29-year-old.

During Super Bowl 59 weekend, Deebo Samuel confirmed that the 49ers gave him and his agent permission to seek a trade. The 2021 All-Pro has one season remaining on a three-year deal he signed in the 2022 offseason.

Samuel is coming off a disappointing season in which he recorded just 51 catches for 670 yards and three touchdowns. San Francisco’s offense can get by without Samuel thanks to the presences of Christian McCaffrey, George Kittle, Brandon Aiyuk, 2024 breakout star Jauan Jennings and first-round pick Ricky Pearsall.

A healthy Samuel is always a threat for 1,000 yards of offense (he had a career-high 1,770 in 2021), but the cap-strapped 49ers have an easy call to move on and proceed with their current set of playmakers.

The Buffalo Bills need a No. 1 receiver after trading Stefon Diggs last year, and with Amari Cooper likely to hit free agency. The defending AFC champions are the ideal landing spot for Samuel, who would immediately slot in as Josh Allen’s top pass-catcher.

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Allen won MVP honors in 2024 and got the Bills within a few plays of the Super Bowl despite lacking a true No. 1 threat. Khalil Shakir was his lead receiver with 76 catches for 821 yards and four touchdowns.

What Bills Should Offer 49ers For Deebo Samuel

The Bills should offer the 49ers one of their two 2025 fifth-round picks (No. 171 or No. 175 overall) and their 2026 third-round selection for Samuel. It’s a fair price for an explosive pass-catcher, albeit an injury-prone player who’s entering his contract year.

For San Francisco, trading Samuel is mostly about clearing cap space here. Getting two draft picks for a player who needs a fresh start would be a small victory for GM John Lynch.